Although Meg Ryan began her acting career in 1981, starring in minor roles before joining the cast of the CBS soap opera As the World Turns in 1982, the actress ultimately rose to fame after starring in a series of hit romantic comedies in the 1990s, including When Harry Met Sally... which earned her a Golden Globe Award nomination for Best Lead Actress in a Motion Picture — Comedy or Musical. Ryan has become one of the biggest and most bankable stars in Hollywood ever since.